Editorial: giving high-grade help to low-grade dysplasia
نویسندگان
چکیده
منابع مشابه
Differential LINE-1 Hypomethylation of Gastric Low-Grade Dysplasia from High Grade Dysplasia and Intramucosal Cancer
BACKGROUND/AIMS Gastric epithelial dysplasia is considered a precancerous lesion with a variable clinical course. There is disagreement, however, regarding histology-based diagnoses, which has led to confusion in choosing a therapeutic plan. New objective markers are needed to determine which lesions progress to true malignancy. We measured LINE-1 methylation levels, which have been reported to...
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Pseudomyxoma peritonei (PMP) is a rare disease exhibiting a distinct clinical feature caused by cancerous cells that produce mucinous fluid in the abdominal cavity. PMPs originate most frequently from the appendix and less frequently from the ovary. This disease can range from benign to malignant, and histologically, PMP is classified into two types: disseminated peritoneal adenomucinosis (DPAM...
متن کاملHistologically benign or low-grade malignant tumors adjacent to high-grade ovarian carcinomas contain molecular characteristics of high-grade carcinomas.
It is presently not clear if ovarian carcinomas arise de novo or from benign precursors (cystadenomas) and if high-grade malignant tumors (carcinomas) develop from preexisting low-grade carcinomas. The presence of allelic losses on chromosome 11p15.5 distinguishes high-grade ovarian carcinomas from either low-grade carcinomas or cystadenomas. We therefore examined the distribution of such losse...
متن کاملCurrent Management of Low-Grade Dysplasia in Barrett Esophagus.
Low-grade dysplasia in Barrett esophagus remains an ongoing challenge in clinical management. Recent studies suggest an increased risk in progression of low-grade dysplasia to high-grade dysplasia and/or adenocarcinoma. This is especially seen when 1 or more expert gastrointestinal pathologist confirms the diagnosis and in the setting of low-grade dysplasia that persists on more than 1 endoscop...
متن کاملLow-Grade Dysplasia in Patients with Barrett’s Esophagus — Ablate?
A 73-year-old, obese white male with a history of hypertension and obstructive sleep apnea noted new onset nocturnal heartburn for six weeks. He was prescribed Ranitidine 150 mg orally at night by his primary care doctor, which initially controlled his symptoms. Three months later he noted substernal “burning” after eating spicy or high fat foods and returned to his primary care physician. Cons...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2019
ISSN: 0269-2813
DOI: 10.1111/apt.15257